APRIL 4, 2023 CHEMOTHERAPY DERIVED FROM PLANTS

I see many patients with cancer. I feel it is overwhelming at times. Much of chemotherapy is synthetic. Some chemotherapy is derived from plants. There are well known chemotherapy derived from the periwinkle plant. These chemotherapies derived from plants are called plant alkaloid

Navelbine belongs to a class of chemotherapy drugs called plant alkaloids. Plant alkaloids are made from plants.  The vinca alkaloids are made from the periwinkle plant (catharanthus rosea). The taxanes are made from the bark of the Pacific Yew tree (taxus).  The vinca alkaloids and taxanes are also known as antimicrotubule agents. The podophyllotoxins are derived from the May apple plant. Camptothecan analogs are derived from the Asian "Happy Tree" (Camptotheca acuminata).  Podophyllotoxins and camptothecan analogs are also known as topoisomerase inhibitors.  The plant alkaloids are cell-cycle specific.  This means they attack the cells during various phases of division.

  • Vinca alkaloids: Vincristine, Vinblastine and Navelbine

  • Taxanes:  Paclitaxel and Docetaxel

  • Podophyllotoxins:  Etoposide and Tenisopide

  • Camptothecan analogs: Irinotecan and Topotecan

Mistletoe is one of the most widely studied CAM therapies for cancer. In certain European countries, the preparations made from European mistletoe (Viscum album, Loranthaceae) are among the most prescribed drugs offered to cancer patients.

Many plants have beneficial effect on killing cancer More plants need to be studied. Curcuma longa ( Tumeric) has been studied by the NIH in the last five years More plants need to be studied . Carnivora ( from the Venus fly trap ) has been studied in Europe

Until tomorrow…