Acute cystitis, or inflammation of the bladder, is caused by a urinary tract infection (UTI). The antibiotics used to treat UTIs alleviate symptoms quickly; however, the use of antibiotics is associated with adverse effects and an increase in antibiotic resistance. The use of antibiotics also disturbs the gut microbiome.
A recent study posted in HerbalGram of the American Botanical Council by Pugliese D, Acampora A, Porreca A, Schips L, Luca C. Effectiveness of a novel oral combination of D-Mannose, pomegranate extract, prebiotics and probiotics in the treatment of acute cystitis in women. Arch Ital Urol Androl. April 6, 2020;92(1):34-38.
I use D mannose for cystitis related to E coli. I never though to combine with the other constituents. The pomegranate (Punica granatum) is a fruit -bearing shrub that grows between 5 and 10 m (16 and 33 ft) tall. When i think of the pomegranate I think of a medicinal plant from the Bible and its use in prostate issues. There was good results from this combination. As with all studies there are small flaws. Yet the authors stated "Our study suggests that the synergistic action of the components of this new combination could help the bacterial washout resulting in an effective management of acute cystitis in women without antibiotics in a wide majority of the cases.”